Regio- and stereoselective reaction of 3-fluoropyridine, electron-deficient alkynes and bis(fluoroalkyl) phosphites: Catalyst- and solvent-free synthesis of polyfluoroalkylphosphonylated 3-fluoro-1,2-dihydropyridines

Abstract The catalyst- and solvent-free reaction between 3-fluoropyridine, electron-deficient alkynes and bis(fluoroalkyl) phosphites occurs under mild conditions (20–22 °C, 1–8.5 h) to stereo- and regioselectively afford 2-bis(polyfluoroalkoxy)phosphoryl- ( E )- N -ethenyl-3-fluoro-1,2-dihydropyridines in 53–69% yield.