Diatrizoate contrast agent study for luminal patency and visualization of the gastrointestinal tract in healthy rabbits (Oryctolagus cuniculus) and its influence on selected blood parameters and fecal quality

Abstract Background The aim of this study was to determine an effective dose of the contrast agent diatrizoate in healthy rabbits. Methods This study included 14 rabbits receiving three different dosages of a solution containing 300 mg iodine/mL and 600 mg diatrizoate/mL (Dose 1, 2 mL/kg; Dose 2, 7 mL/kg; Dose 3, 10 mL/kg). Full body radiographs were obtained at 0, 15, 30, 45 and 60 min, and 12 and 24 h after oral administration. Blood samples 60 min and 24 h after administration and fecal dry matter after 24 h were compared to preliminary samples. Results Recommended doses and times for radiography for luminal patency and visualization of each gastrointestinal segment are given. The evaluated blood parameters were within their respective reference intervals throughout this study. However, significant changes (p Administration of 7 mL/kg and 10 mL/kg resulted in a significant decrease in the dry matter of feces. Five rabbits developed self-limiting diarrhea after administration of 10 mL/kg. Conclusion and clinical relevance Diatrizoate is a useful contrast agent in order to assess the passage through the intestine and achieve a good visualization of the gastrointestinal system.