Multiple Causes of Cardiotoxic Effects in Patients With Chronic Myeloid Leukemia

tics and the treatment response of EGFR-TKI. A possible reason is that the development of lung cancer did not completelydependenton theBIMpathway.Otherpossible survival mechanisms may play an important role after EGFR-TKI treatment.4 Furthermore, BIM protein concentrations have variable effects on apoptosis, and there is a dose-dependent effect of BIM on apoptosis and the degree of TKI resistance.6 In addition,BIMdeletion polymorphism is foundonly in East Asians, but not in the white population.2 In conclusion, BIM deletion polymorphism does not account for intrinsic resistance to EGFR-TKI.