Oxidative Stress Modulation Immediately After Hemodialysis

AIM The aim of this study was to estimate oxidative stress (OS) before and after dialysis in hemodialysis (HD) patients and correlate this stress with routine biochemical parameters. METHOD Sera of patients (n = 21), under regular HD, were collected 5 minutes before and after an HD session. Oxidative stress was estimated using the pro-oxidant-antioxidant assay (PAB), along with routine biochemical parameters in the same sera. RESULTS A significant increase of OS value was observed in HD patients 5 minutes after dialysis. Before HD, a significant correlation was established between the PAB values and fasting blood sugar, calcium, and C-reactive protein (CRP); and an inverse correlation between the PAB values and uric acid, serum creatinine, albumin, and albumin/globulin ratio. This correlation was not obvious after HD. PAB value, after dialysis, correlated significantly only with serum iron and inversely with alanine transaminase. CONCLUSION This study found that the already-increased OS in HD patients is further increased immediately after dialysis. However, factors influencing post-dialysis OS may be different from pre-dialysis factors.