Синтез и биологическая активность 2,3- бис -(2-оксоилиден)-1,3,4,6-тетрагидрохиноксалинов

It is established that condensation of alkyl methyl ketones with diethyl oxalates and 1,2-diaminobenzene yields 2,3- bis -(2-oxoalkylidene)tetrahydro-1,2,3,4-quinoxalines. Structural peculiarities of the synthesized compounds have been investigated by IR, 1 H NMR spectroscopy, and mass spectrometry. With the help of spectral methods, four isomeric forms of synthesized compounds are found. The biological activity of the synthesized compounds has been studied. It is established that one compound (II) possesses analgesic activity that exceeds the activity of sodium metamizole. Compound also exhibits the antioxidant activity, while another compound (V) possesses a pro-oxidant activity. Some compounds showed high antiradical scavenging activity, which did not exceed that trolox.