Abstract 15707: MYK-491, a Novel Small-Molecule Cardiac Myosin Activator Increases Cardiac Systolic Function and Preserves Mechanical Efficiency: Pre-Clinical in vivo and in vitro Evidence

Introduction: Cardiac myosin motors have been shown to efficiently convert ATP to mechanical force. MYK-491 is a novel small-molecule selective allosteric activator of cardiac acto-myosin that leve...