Effects of flurbiprofen on ventilator-induced lung injury in rats

Objective To investigate the effects of flurbiprofen on ventilator-induced lung injury in rats. Methods Forty healthy adult male SD rats weighing 300-350 g were randomly divided into 4 gorups ( n = 10 each) : group A traditional tidal volume (VT= 8 ml/kg) ; group B high tidal volume (HV, VT = 40 ml/kg) ; group C HV + flurbiprefen 5 ms/kg and group D HV + flurbiprofen 10 ms/kg. The animals were anesthetized with intraperitonel 20% urethane 8 ml/kg, tracheostomized and mechanically ventilated. In group C and D flurbiprofen was given iv at 15 rain before mechanical ventilation. The animals were mechanically ventilated for 4 h and then sacrificed. The lungs were removed for determination of TNF-α, IL-6, TXB2 total protein concentrations and WBC count in bronchoalveolar lavage fluid (BALF), W/D lung weight ratio and microscopic examination. Results The TNF-α, IL-6, TXB2, total protein concentrations, the number of WBCs and W/D ratio were significantly higher and the histologic damage was significantly more serious in group B than in group A. Flurbiprofen significantly attenuated the HV-induced changes in group C and D. The TNF-α, TXB2 concentrations in BALF were significantly lower in group D than in group C. Conclusion Fhrbiprofen can attenuate ventilator-induced lung injury in rats. Key words: Flurbiprofen;  Respiration, artificial;  Respiratory distress syndrome,adult