Silver Ion Promoted, Pd-II-Catalyzed Arylation of Arenes with a Free Amine as Directing Group in Aqueous Medium

Palladium(II)-catalyzed arylation of arenes with aryl boronic acids and a free amine as directing group in aqueous medium has been developed. High reactivity and chemoselectivity for the formation of carbon-carbon bonds were achieved by the use of soluble silver salts. The addition of water is crucial to improve the arylation yield.