Relationship between wg Gene and Heart Failure

Heart failure becomes the cause of death in human and its molecular mechanism remains to be revealed.The wg gene plays an important role in controlling the specification and differentiation of the cardiac precursor cells,but it is still unknown whether wg is related to the process of heart failure.The relationship between the wg gene and heart failure was studied by using Drosophila Pacing-Model.The result showed that the rates of heart failure of two wg mutant lines were 52%and 43%,respectively,which was obviously higher than that of wildtype control with a rate of 25%,suggesting that the wg gene may be involved in heart failure regulation.