DIRECT CONVERSION OF ADULT HUMAN FIBROBLASTS INTO AUTHENTIC ENDOTHELIAL CELLS

We report a novel strategy to directly convert adult human dermal fibroblasts (aHDFs) into authentic endothelial cells (ECs). Lentiviral vectors encoding endothelial transcription factors (TFs) were constructed, used to transduce aHDFs. We examined whether 5 TFs (FOXO1, ER71, KLF2, TAL1, and LMO2