Garcinia acid ester derivative and one kind of preparation and use

The present invention relates to an ester derivative of Garcinia and its preparation and use, the derivative of formula such as of formula (I) shown; Preparation method comprising: under nitrogen atmosphere, gambogic acid, gemcitabine and triphenyl phosphine was dissolved in dry tetrahydrofuran, THF injection solution containing diethyl azodicarboxylate DEAD, the reaction 12-24h, washed, dried, rotary evaporation, the product obtained by column chromatography. The derivatives are useful for the preparation of compositions, antitumor, antifungal or anti-angiogenic drugs or with other anticancer active ingredient in combination. Derivatives of the invention not only a variety of cancer cells showed good activity, but also shows excellent tumor targeting, which will provide the basis to develop new drugs.