MP26-04 ROLE OF ADJUVANT CISPLATIN-BASED CHEMOTHERAPY FOLLOWING RADICAL CYSTECTOMY IN MUSCLE-INVASIVE AND LOCALLY ADVANCED BLADDER CANCER: SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED TRIALS

INTRODUCTION AND OBJECTIVES:We aimed to evaluate the effects of adjuvant chemotherapy (ACH) on survival outcomes in patients with muscle-invasive bladder cancer (MIBC) treated with radical cystectomy (RC). A subgroup analysis was also performed to examine effects in patients with locally advanced MIBC.METHODS:A comprehensive literature search was performed in the PubMed, Embase, and Cochrane library databases for all articles published until February. The systematic review and meta-analysis was performed by pooling the randomized controlled trials (RCTs) that compared patients who received ACH after RC with those who underwent cystectomy alone.RESULTS:Eight RCTs with a total of 979 patients were selected for the analysis. These eight trials included patients with MIBC. The pooled hazard ratios (HRs) for progression-free survival (PFS) and overall survival (OS) were 0.61 (95% confidence interval [CI], 0.46–0.80; p = 0.0005) and 0.72 (95% CI, 0.55–0.94; p = 0.02), respectively. Four of the eight trials incl...