Hematopoietic Growth Control by the T-Cell CD2 Determinant is Exerted at a Pretranslational Level

Cellular growth control takes a delicate balance between stimulatory and inhibitory signals. Much previous research has focused on the identification of genes which encode for stimulatory signals. Genes that encode for inhibitory signals may be more difficult to analyze [1]. T-cell gene products are capable of inhibition of hematopoiesis in vitro and possibly in vivo [2–6]. The mechanisms regulating the inhibitory hematopoietic T-cell program are not well understood.