The anti-diabetic drug metformin does not affect bone mass in vivo or fracture healing

J Jeyabalan,Benoit Viollet,Peter Smitham,S A Ellis,Gul Zaman,C. Bardin,Allen E. Goodship,Jean-Paul Roux,M. Pierre,Chantal Chenu

The anti-diabetic drug metformin does not affect bone mass in vivo or fracture healing

2013

J Jeyabalan
Benoit Viollet
Peter Smitham
S A Ellis
Gul Zaman
C. Bardin
Allen E. Goodship
Jean-Paul Roux
M. Pierre
Chantal Chenu

Summary The present study shows no adverse effects of the anti-diabetic drug metformin on bone mass and fracture healing in rodents but demonstrates that metformin is not osteogenic in vivo, as previously proposed.

Keywords:

Metformin
Bone remodeling
Bone density
In vivo
Osteoporosis
Bone healing
Internal medicine
Medicine
Rosiglitazone
Endocrinology
Adverse effect

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