Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity

Susann Fayyaz,Lukasz Japtok,Fabian Schumacher,Dominik Wigger,Tim J. Schulz,Kathrin Haubold,Erich Gulbins,Heinz Völler,Burkhard Kleuser

Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity

2017

Susann Fayyaz
Lukasz Japtok
Fabian Schumacher
Dominik Wigger
Tim J. Schulz
Kathrin Haubold
Erich Gulbins
Heinz Völler
Burkhard Kleuser

Background/Aims: Obesity is a main risk factor for the development of hepatic insulin resistance and it is accompanied by adipocyte hypertrophy and an elevated ex

Keywords:

Lysophosphatidic acid
Insulin resistance
Biochemistry
Diabetes mellitus
Insulin receptor substrate
Insulin receptor
Endocrinology
Adipose tissue
Autotaxin
Internal medicine
Biology
Adipocyte hypertrophy
Protein kinase B
Glycogen
Glycogen synthase

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