TO COMPARE THE EFFECTS OF PITAVASTATIN ON INSULIN RESISTANCE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH HPERCHOLESTEROLEMIA WHO WERE PREVIOUSLY BEING TREATED WITH ATOORVSTATIN

Objective: To compare the effects of Pitavastatin on Insulin Resistance in patients with type 2 diabetes mellitus with hypercholesterolemia who were previously being treated with Atorvastatin. Study Design: Prospective, comparative cross-sectional study. Place and Duration of Study: Combined Military Hospital Sialkot, from Sep 2018 to Dec 2018. Methodology: Our study was a prospective, comparative cross-sectional study, formulated to evaluate the effects of statins on Insulin resistance. A total of 52 patients of Diabetes Mellitus and Hypercholesterolemia who were previously treated with Atorvastatin for at least 12 weeks were enrolled for the study carried out for 3 months. Serum lipid profiles and blood samples were obtained after overnight fast. Insulin resistance was calculated at the start of study for atorvastatin and after 3 months of shifting to Pitavastatin. Results: At initiation of the study no statistically significant differences were found in the baseline BMI, HDL-C, triglycerides or HbA1c. Homeostatic Model Assessment of Insulin Resistance (HOMA_IR) was employed to calculate Insulin resistance at the start of study and after 3 months of shifting to Pitavastatin. There was a significant reduction in Insulin resistance (p=0.031) after three months of shifting the patient from Atorvastatin to Pitavastatin. Conclusion: Pitavastatin treatment in comparison to Atorvastatin had statistically significant reduction in Insulin resistance in patients with type 2 Diabetes Mellitus.