Severely impaired respiratory chain causes multisystem apoptosis-driven developmental defects, a new mitochondrial phenotype in vertebrates

A. Indrieri, V. van Rahden, V. Tiranti, I. Conte, J. Quartararo, M. Morleo, D. Iaconis, R. Tammaro, G. Chesi , M. Cermola, R. Tate, I. Maystadt, S. Demuth , A. Zvulunov, I. D’Amato, P. Goffrini, I. Ferrero, P. Bovolenta, K. Kutsche , M. Zeviani, B. Franco Telethon Institute of Genetics and Medicine (TIGEM), Napoli Institut fur Humangenetik, Universitatsklinikum Hamburg-Eppendorf, Hamburg, Germany UO Neurogenetica Molecolare, Fondazione IRCCS Istituto Neurologico "C. Besta", Milano Dip di Genetica, Biologia dei Microrganismi, Antropologia, Evoluzione, Universita degli Studi di Parma, Parma Microscopia Integrata, Instituto di Genetica e Biofisica "Adriano Buzzati Traverso", CNR, Napoli Centre de Genetique Humaine, Institut de Pathologie et de Genetique, Gosselies (Charleroi), Belgium Gemeinschaftspraxis fur Humangenetik, Erfurt, Germany; Schneider Children's Medical Center of Israel, Ben-Gurion University of the Negev, Beer-Sheva, Israel Centro de Biologia Molecular “Severo Ochoa”, CSIC-UAM and CIBER de Enfermedades Raras (CIBERER), Madrid, Spain Telethon Institute of Genetics and Medicine (TIGEM), Napoli, Dip di Pediatria, Universita degli Studi di Napoli "Federico II", Napoli.