A Genome Wide Association Study of Plasmodium falciparum Susceptibility to 22 Antimalarial Drugs in Kenya

Jason P. Wendler,John Okombo,Roberto Amato,Olivo Miotto,Steven M. Kiara,Leah Mwai,Lewa Pole,John D. O'Brien,Magnus Manske,Dan Alcock,Eleanor Drury,Mandy Sanders,Samuel O. Oyola,Cinzia Malangone,Dushyanth Jyothi,Alistair Miles,K Rockett,Bronwyn MacInnis,Kevin Marsh,Philip Bejon,Alexis Nzila,Dominic Kwiatkowski

A Genome Wide Association Study of Plasmodium falciparum Susceptibility to 22 Antimalarial Drugs in Kenya

2014

Background Drug resistance remains a chief concern for malaria control. In order to determine the genetic markers of drug resistant parasites, we tested the genome-wide associations (GWA) of sequence-based genotypes from 35 Kenyan P. falciparum parasites with the activities of 22 antimalarial drugs.

Keywords:

Drug resistance
Genetic marker
Virology
Antibiotic resistance
Plasmodium falciparum
Haplotype
Pharmacology
Genotype
Genome-wide association study
Malaria
Medicine
malaria control

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