[3+2] Cycloaddition of arynes with CF3CHN2: Access to 3-trifluoromethyl-1H-indazoles

Abstract Efficient [3 + 2] cycloaddition reactions of arynes and CF 3 CHN 2 were developed in the presence of fluoride in conjunction with TEBAC. Structurally distinct 3-trifluoromethyl-1 H -indazoles were obtained in good to high yields with moderate regioselectivities. This experimentally simple process facilitates the access to potential biologically active 3-trifluoromethyl-indazoles from readily available starting materials.