Comment on “The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele”

STING is a signaling protein encoded by the human TMEM173 gene that is central to the host response to infection. Upon binding cyclic dinucleotides (CDNs), STING activates transcriptional programs that orchestrate innate and adaptive immune responses ([1][1], [2][2]). For this reason, STING is a