Peripheral T-cell lymphoma developed in a patient with 4-year-latency following transient systemic lymphadenopathy.

A 36-year-old male developed systemic lymphadenopathy with Coombs-positive hemolytic anemia and polyclonal hypergammaglobulinemia.Histological diagnosis of the biopsied lymph node was undetermined, and suspected of reactive lymphadenopathy probably due to viral infection. The symptoms spontaneously disappeared within a half year.Systemic lymphadenopathy recurred 4 years later without hemolytic anemia and polyclonal hypergammaglobulinemia. Biopsied lymph node was diagnosed as peripheral T-cell lymphoma. The lack of manifestation of immunological abnormalities at the neoplastic stage of the disease suggests the probable different clonal origins of cells proliferating in the lymph node biopsied initially. The patient achieved complete remission by CHOP therapy, and remains free of disease a year to date.