Primary Cardiac Lymphoma

Abstract Objective This study aimed to understand the population-level treatment modalities and to evaluate the survival benefits of surgical resection in primary cardiac lymphoma. Methods We queried the Surveillance, Epidemiology, and End Results database, which covers 35% of the US population. Patients with a histological diagnosis of primary cardiac lymphoma from 1973 to 2015 were included. Multivariable accelerated failure time regression was performed to evaluate the associations between clinical factors and overall survival. Results A total of 184 patients were identified. The median age was 68 years, with 80% being white and 46% being female. Diffuse large B-cell lymphoma (80%) was the most common histology, and the majority (65%) were low stage lymphoma (Ann Arbor Stage I/II). Median survival was 2.2 years. Seventy-three percent of the patients received chemotherapy. Only 10% of patients received local resection or debulking. Multivariable analysis demonstrated that local resection or debulking was not independently associated with overall survival (aHR = 0.67; 95%CI: 0.30, 1.48; p = 0.32). Instead, chemotherapy (aHR = 0.4; 95%CI: 0.23, 0.69; p Conclusion Surgical resection was not independently associated with survival in primary cardiac lymphoma patients. Chemotherapy was the predominant treatment option and associated with improved survival while increasing age and advanced stage were independently associated with worse outcomes.