Fungal causes of otitis externa and tympanostomy tube otorrhea

Summary Objective: To describe the occurrence of fungal organisms in the setting of otitis externa and tympanostomy tube otorrhea, review the treatment course, timing of diagnosis, organism identified and time to resolution with fungal infections. Design: Retrospective review. Setting: Pediatric otolaryngology clinic within a tertiary care hospital. Patients: One hundred and sixty-six patients (ages 16 days to 18 years) with fungal organisms on ear culture. Outcome measures: Number of prior therapies, number of office visits, time to resolution and anti-fungal therapy. Results: Ear cultures positive for fungal organisms were found in 166 patients seen between 1 January 1996 and 30 September 2003 from a total of 1242 patients undergoing ear culture. Comparing the 3-year period (1996–1998) prior to the availability of fluoroquinolone ototopical drops to the 3-year period after (1999–2001), there is a statistically significant increase in the incidence of positive fungal culture ( p Candida albicans was identified in 43% of fungal organism-positive cultures. Candida parapsilosis was found in 24% of and Aspergillus fumigatus in 13%. The remainder of the cultures yielded three other Candida and three other Aspergillus species, each at less than 5%. Time to resolution ranged from 1 week to 9 months, with a median of 3.8 weeks for symptom resolution. Patients were treated with an average of 1.7 oral antibiotics and 1.1 ototopical agent before a culture was taken. Conclusions: Otorrhea due to fungal organisms occurs in the setting of refractory infection and is often discovered after multiple oral and ototopical antibacterial medications. Due to the extended treatment period required to clear fungal organism, timely diagnosis with culture for bacteria and fungus is required in patients with persistent otorrhea. An increase in incidence of fungal infections of the ear was found in the period after widespread use of ofloxacin began.