Retrospective study of orthovoltage radiation therapy for nasal tumors in 42 dogs.

2001 
Megavoltage radiation therapy currently is the standard of care for dogs with nasal tumors. Some studies report that surgery andadjunctive orthovoltage radiation therapy result in longer control of these tumors than does megavoltage radiation therapy alone.This study reports less effective control of nasal tumors in dogs treated with surgery and orthovoltage radiation than previouslyobserved, supporting the superiority of megavoltage radiation therapy for these tumors. In addition, this study suggests 2 newprognostic indicators for dogs with nasal tumors and describes toxicity associated with surgery and orthovoltage therapy. Forty-two dogs with nasal tumors were treated with surgical cytoreduction and 48 Gy orthovoltage radiation therapy administered intwelve 4-Gy fractions. Median survival was 7.4 months. One- and 2-year survival rates were 37% and 17%, respectively. Dogswith facial deformity had shorter survival than those without deformity (P .005). Dogs with resolution of clinical signs aftertreatment had longer survival than those with chronic nasal signs (P .0001). Acute radiation toxicity was moderate to severefor skin and eye and negligible for oral mucosa. Toxicity healed within 1 month after radiation therapy. Late toxicity was mild,but 70% of evaluable dogs experienced persistent ocular signs. Only 39% of dogs achieved a disease-free period.Key words: Cancer; Canine; Neoplasia; Respiratory.
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