Clinical Outcome and Predictors of Favorable Result after Laparoscopic Magnetic Sphincter Augmentation: Single Institution Experience with over 500 Patients
2020
Introduction Magnetic sphincter augmentation (MSA) is a promising surgical treatment for patients with GERD. The aim of this study is to evaluate the outcome of MSA in a large cohort of GERD patients and to determine the factors predicting a favorable outcome. Methods This is a retrospective review of prospectively collected data of 553 patients who underwent MSA at our institution in a 5-year period. Preoperative clinical, endoscopic, manometric and pH data were used in a univariate analysis. This was followed by a regression multivariable analysis to determine the factors predicting a favorable outcome. Favorable outcome was defined as freedom from PPI and 50% or more improvement in GERD-HRQL total score. Results At a mean follow up of 10.3 (10.6) months after MSA, 89.9% of the patients were free of PPI use and 84% reported at least 50% improvement in their GERD-HRQL total score. GERD-HRQL total score was improved from baseline value of 33.8 (18.7) to 7.2 (9.0) (p 15 (OR:7.5 (95% CI: 3.3–16.8, p Conclusion In this largest single-institution series, we demonstrate that MSA implantation is associated with very good clinical and objective outcome. Age 15 and abnormal DeMeester score are the four preoperative factors predicting a favorable outcome and can be used in patient counseling and MSA utilization.
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