Micellar thermodynamics of voriconazole cyclodextrin-HS15 complex in glucose and NaCl solution

The hydrodynamic radius and size dispersion of cyclodextrin-micelle complexes loaded with voriconazole in glucose and NaCl solutions were studied in detail by dynamic light scattering technique. The critical micelle concentration (CMC) was determined by surface tension, and the relevant air–water interface parameters and micellization thermodynamic parameters were calculated. In the environment of glucose and NaCl, the CMC value decreases with the increase in the concentration of the additive. Glucose forms more stable hydrophilic ends by binding to the micelle hydrophilic group. NaCl acts as a water structure building ion to provide hydrophobic force to the gum surfactant molecules and promote the formation of micelles. The results of insoluble particles are consistent with the CMC results, which further supports the results obtained.