PREDICATION OF BIOLOGICAL ACTIVITY OF ALGAL ANTITUMOR DRUGS USING PASS

Summary The computer system PASS provides simultaneous predication of several hundreds of biological activity types of any drug like compounds. Over the past decade seaweeds have become an interesting source of new classes of pharmacologically active natural products. The majority of biologically active compounds have both pharmacotherapeutic and side/toxic actions. To estimate general efficacy and safety of the molecules under study, their biological potential should be thoroughly evaluated. In this study the PASS (Predication of activity spectra for substances)computer program, which is able to simultaneously predict more than one thousand biological and toxicological activities from only the structural formulas of the chemicals, was used to predict the biological activity profile of 19 algal secondary metabolites. PASS predications were successfully compared to the available information on the pharmacological and toxicological activity of these compounds.