A Method for Determining the Kinetics of Small-Molecule-Induced Ubiquitination.

Ellen F. Vieux,Roman V. Agafonov,Lydia Emerson,Marta Isasa,Richard W. Deibler,Jeffrey R. Simard,David Cocozziello,Brendon Ladd,Linda Lee,Heng Li,Stephen Archer,Mark E. Fitzgerald,Ryan E. Michael,Christopher G. Nasveschuk,Eunice S. Park,Günther Kern,David A. Proia,Andrew J. Phillips,Stewart L. Fisher

A Method for Determining the Kinetics of Small-Molecule-Induced Ubiquitination.

2021

Ellen F. Vieux
Roman V. Agafonov
Lydia Emerson
Marta Isasa
Richard W. Deibler
Jeffrey R. Simard
David Cocozziello
Brendon Ladd
Linda Lee
Heng Li
Stephen Archer
Mark E. Fitzgerald
Ryan E. Michael
Christopher G. Nasveschuk
Eunice S. Park
Günther Kern
David A. Proia
Andrew J. Phillips
Stewart L. Fisher

Recent advances in targeted protein degradation have enabled chemical hijacking of the ubiquitin–proteasome system to treat disease. The catalytic rate of cereblon (CRBN)-dependent bifunctional deg...

Keywords:

Small molecule
Biophysics
Chemistry
Catalytic rate
protein degradation
Bifunctional
Ubiquitin
Cereblon
Kinetics

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