Voxel-based morphometry in patients with mood disorder bipolar I mania in comparison to normal controls

Background Neuroimaging is used to study brain structural alterations in neuropsychiatric diseases including bipolar disorder (BD). Voxel-based morphometry (VBM) quantifies structural changes detected in magnetic resonance imaging (MRI). The aim of this study was to identify brain structural changes in patients with mood disorder bipolar I mania, compared to healthy controls; and detect any correlations between volumetric findings and different clinical aspects of the disease. VBM was used to identify structural changes in 24 patients with bipolar I mania compared to 16 controls. Young Mania Rating Scale (YMRS) was used to evaluate clinical severity of BD. t test was used to compare differences in volumetric data and Spearman’s rank correlation coefficient was used to detect potential correlations between volumetric data and clinical parameters of BD.