SP645QUANTITATIVE COMPUTED TOMOGRAPHY RESULTS FOR BONE MASS AND ABDOMINAL AORTIC VASCULAR CALCIFICATION IN HEMODIALYSIS SUBJECTS TREATED WITH ESCALATING DOSE LEVELS OF SOTATERCEPT: INTERIM ANALYSIS OF ACE-011-REN-001

• Renal osteodystrophy (ROD) and vascular calcification (VC) are integral components of chronic kidney disease-mineral/bone disorder (CKD-MBD). CKD-MBD is strongly associated with greatly increased morbidity and mortality in end-stage kidney disease (ESKD).1 • Activin A is a transforming growth factor-β superfamily protein that is found at high levels in bone; its signaling is through the type II activin A receptor (ActRIIA).2-4 Inhibin, an inhibitor of activin A signaling, is produced in the ovaries and stimulates bone growth.2,5 Decreased inhibin expression is associated with post-menopausal bone loss.5