Genome-wide compendium and functional assessment of in vivo heart enhancers.

Diane E. Dickel,Iros Barozzi,Yiwen Zhu,Yoko Fukuda-Yuzawa,Marco Osterwalder,Brandon J. Mannion,Dalit May,Cailyn H. Spurrell,Ingrid Plajzer-Frick,Catherine S. Pickle,Elizabeth A. Lee,Tyler H. Garvin,Momoe Kato,Jennifer A. Akiyama,Veena Afzal,Ah Young Lee,David U. Gorkin,Bing Ren,Edward M. Rubin,Axel Visel,Len A. Pennacchio

Genome-wide compendium and functional assessment of in vivo heart enhancers.

2016

Identification of non-coding variants has outstripped our ability to annotate and interpret them. Dickel et al. present a compendium of over 80,000 putative human heart enhancers and demonstrate that two conserved enhancers are required for proper cardiac function in mice.

Keywords:

Regulation of gene expression
Genetics
Genome
In vivo
Compendium
Enhancer
Epigenomics
Transcriptional Regulatory Elements
Biology
Heart disease
Gene
Phenotype
Disease
Bioinformatics
Cardiac function curve

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