The anticonvulsant action of methazolamide in mice: antagonism by various inhibitors of dopamine β-hydroxylase

Abstract The dopamine β-hydroxylase inhibitors, FLA-63 and picolinic acid, antagonized of anticonvulsant action of methazolamide in mice; disulfiram and pyrimidinethiol were inactive. FLA-63 and picolinic acid, but not disulfiram or pyrimidinethiol prevented pheniprazine restoration of the anticonvulsant action of methazolamine in reserpized mice. The present findings clearly demonstrate that differences exist among inhibitors of dopamine β-hydroxylase redarding their ability to antagonize the anticonvulsant action of methazolamide under various test conditions.