Gonadal tumor and malignancy in 118 patients with disorders of sex development with Y chromosome.

OBJECTIVE To provide more information about tumor prevalence and malignant transformation among disorders of sex development (DSD) patients for further guidance in prophylactic gonadectomies and surveillance. METHODS SPSS software (version 20.0) was used for all statistical analyses. RESULTS phenotypic female DSD patients with Y chromosome have a higher risk of gonadal malignancy. CONCLUSION The bilateral gonadal resection is recommended as soon as the diagnosis for phenotypic female patients with disorders of sex development with Y chromosome.