How an intrinsic ligand tunes the activity of a potassium channel

The KCNH family of ion channels (comprising the ether-a-go-go [EAG], EAG-related [ERG], and EAG-like [ELK] subgroups) are voltage-gated potassium channels that play important roles in regulating electrical activity in the brain and heart ([Warmke and Ganetzky, 1994][1]). These large proteins span