RELIABILITY OF ANTI-MULLERIAN HORMONE AND OTHER SEX HORMONES AS MARKERS OF PCOD

Polycystic ovarian disorder (PCOD) is one of the leading endocrine disorder in women of reproductive age. It is a heterogenous complex syndrome affecting the metabolic, endocrine and reproductive functions. Anti-Mullerian hormone (AMH) is a dimeric glycoprotein belonging to the transforming growth factor-beta family. It is secreted by the pre-antral follicles of ovaries. In PCOD, the follicles fail to mature and there is increased number of pre and small antral follicles which leads to hormonal imbalance of AMH, androgens and other sex hormones. The present study was planned to assess the reliability of various endocrine markers viz. AMH, LH, FSH, Estradiol (E2) and Testosterone as markers of PCOD. Based on the Rotterdam consensus, 57 infertile females were diagnosed for PCOD following initial screening, baseline hormone study and transvaginal sonography (TVS). The endocrine data of the above females was compared with that of normal females which constituted the control group (n = 50). The hormone levels in the PCOD group were compared with that of the control group by applying student’s ttest. Women with PCOD showed higher serum AMH and LH/FSH ratio. A significant rise was also observed in serum testosterone levels, while serum FSH showed a decrease which further confirmed the increase in LH/FSH ratio. Women with PCOD have a significantly higher AMH level as compared to normal females of similar age. The study recommends inclusion of increased serum AMH levels and LH/FSH ratio in the inclusion criteria of PCOD.