To Evaluate the Efficacy and Safety of Dexmedetomidine on Hemodynamic Stability in Patients Undergoing Laproscopic Cholecystectomy

Introduction: Peritoneal insufflation of intra-abdominal pressure >10 mmHg induces a significant alteration of hemodynamics. Use of ?-2 adrenergic agonists Dexmedetomidine significantly reduces hemodynamic changes and anesthetic requirements as it has sedative, analgesic, and anxiolytic properties. Methods: 100 patients of ASA I- II undergoing laparoscopic cholecystectomy were randomly allocated into two groups of 50 patients each. Group I patients received dexmedetomidine infusion at 0.2?g/kg/hr and Group II patients received normal saline infusion at 0.2?g/kg/h starting after intubation and continued till peritoneal deflation. Parameters noted were pulse rate, mean arterial pressure, oxygen saturation, EtCO2 and isoflurane requirement. Results: In dexmedetomidine group, the haemodynamic response was significantly attenuated. The anaesthetic requirement was also less with dexmedetomidine group without any desaturation. Conclusion: Dexmedetomidine infusion in the dose of 0.2?g/kg/h effectively attenuates haemodynamic stress response to pneumoperitoneum during laparoscopic surgery. Key words: Dexmedetomidine, haemodynamic stress response, laparoscopic cholecystectomy, pmeumoperitoneum.