Hypervalent iodine-mediated oxygenative phenol dearomatization reactions
2010
Both l 3 - and l 5 -iodanes have proven to be useful reagents in the oxygenative dearomatization of phenols, and exploitations of their chemistry in the conception of both substrate- and reagent-controlled asymmetric variants of such a transformation of great value for natural product synthesis have shown evident signs of success. Moreover, the use of stabilized IBX (i.e., SIBX) in our methodology for O-demethylation of 2-methoxyphenols, which relies on the same key oxygenating dearomatization event, is reported here to be much more efficacious than that of IBX itself in the chemoselective one-step conversion of homovanillyl alcohol into hydroxytyrosol, and bergenin into norbergenin.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
96
References
102
Citations
NaN
KQI