Transition-Metal-Catalyzed Hydroaminocarbonylations of Alkenes and Alkynes

While the amide bond is one of the most widespread backbones in natural peptides, pharmaceuticals, and agrochemicals, the atom-economic synthesis of amides remains a major challenge in organic chemistry. In this context, transition-metal-catalyzed hydroaminocarbonylation of cost-effective alkenes and alkynes has emerged as an ideal approach to access amides. However, it is only in recent times that more chemo- and regioselective hydroaminocarbonylation transformations, covering large substrate scope and under milder conditions, have been reported. In this review, we highlight some recent contributions to this field and elucidate the impact of ligands on regioselectivity, as well as discuss the potential applications of abundantly available nitrogen sources for hydroaminocarbonylation.