The effect of simultaneous exposure to cigarette smoke and noise on distortion product otoacoustic emissions in rats

Cigarette smoking is a possible risk factor for hearing loss. However, the impact of simultaneous exposure to noise and smoke on hearing has remained controversial. This study investigated the combined effect of exposure to cigarette smoking and noise on hearing loss. Three groups of male Wistar rats (275 ± 25 g) were subjected to white noise (102 ± 0.5 dB), cigarette smoking (20 cigarettes), and both cigarette smoking and noise for 8 h and 10 days inside the exposure chamber. The control group was exposed to neither noise nor smoke. Distortion product otoacoustic emissions (DPOAE) were measured before any intervention, and it was repeated 1, 7, and 21 days after the last exposure. One-day postexposure to noise, cigarette smoking, and both cigarette smoking and noise, the mean of DPOAE amplitudes decreased significantly (p < 0.05) between, respectively, 5.7–30.7, 1.5–7.5, and 5.2–32.6 dB within the frequency range of 4620–9960. Temporal DPOAE change in rats exposed to noise or both cigarette smoking and n...