Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies

Venkateshwar Rao Gummadi,Anima Boruah,Bharathi Raja Ainan,Brahma Reddy Vare,Srinivas Manda,Hari Prakash Gondle,Shiva Nagendra Kumar,Subhendu Mukherjee,Suraj T. Gore,Narasimha Rao Krishnamurthy,Sivapriya Marappan,Shilpa S. Nayak,Kavitha Nellore,Wesley Roy Balasubramanian,Archana Bhumireddy,Sanjeev Giri,Sreevalsam Gopinath,DS Samiulla,Girish Daginakatte,Aravind Basavaraju,Shekar Chelur,Rajesh Eswarappa,Charamanna Belliappa,Hosahalli Subramanya,Robert N. Booher,Murali Ramachandra,Susanta Samajdar

Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies

2020

Small molecule potent IRAK4 inhibitors from a novel bicyclic heterocycle class were designed and synthesized based on hits identified from Aurigene’s compound library. The advanced lead compound, C...

Keywords:

IRAK4
Small molecule
Bioavailability
Combinatorial chemistry
Chemistry
Lead compound
Bicyclic molecule

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