Crystal structure of a mirror-image L -RNA aptamer (Spiegelmer) in complex with the natural L- protein target CCL2

Spiegelmers are ‘mirror image’ L-ribose oligonucleotides being developed as therapeutics. Here the authors present a crystal structure of the therapeutic L-aptamer NOX-E36 bound to the pro-inflammatory chemokine CLL2, providing insight into NOX-E36’s selectivity and mode of action.