A Mesoscopic Oblique Plane Microscopy (OPM) Platform for Centimeter Scale Volumetric Imaging

Wenjun Shao,Kıvılcım Kılıç,Wenqing Yin,Gregory Wirak,Xiaodan Qin,Hui Feng,David A. Boas,Christopher V. Gabel,Ji Yi

A Mesoscopic Oblique Plane Microscopy (OPM) Platform for Centimeter Scale Volumetric Imaging

2021

Wenjun Shao
Kıvılcım Kılıç
Wenqing Yin
Gregory Wirak
Xiaodan Qin
Hui Feng
David A. Boas
Christopher V. Gabel
Ji Yi

We implemented a novel optical design to allow using low numerical aperture objective lens in OPM and achieved centimeter-scale volumetric imaging. It has great potential in large specimen imaging such as whole-brain imaging of mice.

Keywords:

Microscopy
Preclinical imaging
Mesoscopic physics
Lens (optics)
Optical performance monitoring
Numerical aperture
Materials science
Optics
Image processing
scale

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