ADJUVANT TREATMENT OF POSTMENOPAUSAL PATIENTS WITH HIGH RISK PRIMARY BREAST CANCER Results from the Danish adjuvant trials DBCG 77 C and DBCG 82 C
1988
The efficacy of adjuvant treatment with tamoxifen was evaluated in protocol DBCG 77°C. Postmenopausal high risk patients (tumor >5 cm, positive axillary nodes, or invasion to skin/fascia) were randomized after total mastectomy and axillary sampling to postoperative radiotherapy (control) or to radiotherapy plus treatment with tamoxifen (TAM), 30 mg daily for 1 year. A total of 1716 patients entered the study. At 8 years of follow-up, (7 years median time of observation), we observed a significant increase of recurrence-free survival for the TAM treated group and a reduction in mortality, which is significant for patients less than 70 years of age. Retrospectively, an increased recurrence-free survival in TAM treated patients was significant in the following subgroups: tumor 100 fmol/mg cytosol protein. In the subsequent trial (DBCG 82 C), 1347 postmenopausal patients < 5 years were randomized to one of the following 3 regimens: ...
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