Impact of night sleep duration on glycemic and triglyceride levels in Chinese with different glycemic status 不同血糖水平的中国人群的夜晚睡眠时间对血糖和甘油三酯水平的影响

Background The aim of the present study was to assess the relationship between night sleep duration and glycemic and triglyceride (TG) levels among people with different glycemic status. Methods In all, 18 121 subjects aged ≥40 years were enrolled in this cross-sectional study, including 4318 with impaired glucose regulation (IGR), 4225 with diabetes, and 9578 with normal glucose regulation (NGR). The IGR + diabetes and NGR groups were divided into three subgroups according to self-reported night sleep duration as follows: (i) 9 h. The associations of sleep duration with HbA1c, fasting plasma glucose (FPG), 2-h post-load plasma glucose (PPG), and TG levels were examined. Results Long night sleep duration (>9 h) was associated with higher HbA1c, FPG, PPG, and TG levels compared with sleep duration of 6–9 h (P < 0.01 for all) in the IGR + diabetes group, but not in the NGR group. This association was adjusted for potential confounders, including body mass index and depressive symptoms, and remained significant even after adjusting for snoring. A significant interaction between sleep duration and TG or snoring was observed for HbA1c levels, which attenuated the sleep–HbA1c association in the IGR + diabetes group. However, no significant association was observed between short night sleep duration and HbA1c levels. Conclusions Long night sleep duration is associated with higher HbA1c, FPG, PPG, and TG levels in IGR and diabetes patients, independent of potential confounders. This may be important in clinical management of IGR and diabetes patients. 摘要 背景：评估不同血糖水平人群的夜间睡眠时间与血糖和甘油三酯水平的关系。 方法：18121名年龄≥ 40岁的患者参与了本次横断面研究，包括糖调节受损（impaired glucose regulation，IGR）的患者4318名，糖尿病患者4225名，糖调节正常（normal glucose regulation，NGR）的患者9578名。根据自我报告的夜间睡眠持续时间又分成三个亚组：（i）夜间睡眠持续时间 9小时。分别对睡眠持续时间与HbA1c、空腹血糖（FPG）、餐后2小时血糖（PPG）、甘油三酯（TG）水平的关系进行了研究。 结果：在IGR和糖尿病患者中，与夜间睡眠时间正常组（6-9小时）相比，夜间睡眠时间较长组（>9小时）的患者具有较高的HbA1c、FPG、PPG和TG水平（P值均<0.01）。在校正了混杂因素包括BMI、抑郁症状，甚至打鼾情况后，该关联仍然显著。但是，在IGR和糖尿病患者中，由于HbA1c水平与睡眠时间和TG或打鼾之间存在显著的交互作用，可能消弱了HbA1c与睡眠的关联。此外，并未发现较短的夜间睡眠时间（<6小时）对HbA1c水平具有显著影响。 结论：对于IGR和糖尿病患者来说，夜间睡眠时间较长与较高的HbA1c、FPG、PPG和TG水平相关。这可能对IGR和糖尿病患者的临床管理具有重要提示作用。