Mild Non-Transition Metal Catalyzed Deprotection of N-Allyloxycarbonyl Amines.
2005
Abstract A synthesis of methyl (2 S )-2-amino-4-oxo-2,4-diphenylbutanoate has been achieved via a novel one-pot non-transition metal mediated deprotection of the N -allyloxycarbonyl amine using iodine in wet acetonitrile. The applicability of this transformation has been demonstrated by deprotecting a variety of N -allyloxycarbonyl amines, α-aminomethyl esters and simple N -allyloxycarbonyl alkyl amines. Deprotection occurs in high yield (82–93%) without erosion of the optical purity of the chiral substrates.
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