Fibrinogen cooperates with cytokines to induce interleukin-6 receptor mRNA expression in human hematopoietic CD34+ progenitors.

INTRODUCTION Many in vitro cultures of hematopoietic progenitors are performed using concentrations of cytokines higher than necessary. It has been observed that high concentrations of cytokines might have a positive effect on the growth of late progenitors, but the opposite effect on earlier stem/progenitor cells by down-regulating receptor expression on these cells [1, 2]. It is therefore important, when defining hematopoietic culture [...]