Antitumoral Effect of Sunitinib-eluting Beads in the Rabbit VX2 Tumor Model

Our study shows that transcatheter arterial chemoembolization (TACE) with sunitinib-eluting beads (SEBs) was safe and resulted in high intratumoral sunitinib concentration with minimum systemic levels; tumor control was better with SEB TACE than with oral sunitinib, probably because of sustained inhibition of vascular endothelial growth factor receptor type 2 phosphorylation and subsequent inhibition of postembolization tumor angiogenesis rebound.