Reduced Lower-Limb Muscle Strength in Type 2 Diabetes Patients with Arthritis Is Associated with Impaired Beta-Cell Function

Insulin levels might affect the integrity of musculoskeletal structures. We hypothesized that in type 2 diabetes patients (T2D) with arthritis musculoskeletal impairment is associated with insulin secretion. This analysis of the German Diabetes Study comprised T2D with (T2D+A (n[m/f]=12[4/8], age 63±9 years, BMI 34.8±7.2 kg/m 2 ) or without arthritis (T2D-A: 22[12/10], 59±13 years, 32.8±6.5 kg/m 2 ) and healthy controls (CON: 18[10/8], 42±16 years, 25.3±4.1 kg/m 2 ). Group comparison analyses were adjusted for age, sex and BMI. T2D duration was - ¹*min - ¹), but lower than in CON (11.5±3.3 mg*kg - ¹*min - ¹, p In conclusion, musculoskeletal impairment is associated with decreased beta-cell function in T2D patients suffering from arthritis, possibly mediated by chronic hyperglycemia. Disclosure O.P. Zaharia: None. D. Pesta: None. P. Bobrov: None. Y. Kupriyanova: None. K. Bodis: None. V. Burkart: None. J. Hwang: None. K. Mussig: None. M. Roden: Speaker9s Bureau; Self; Boehringer Ingelheim GmbH. Research Support; Self; Boehringer Ingelheim GmbH. Consultant; Self; Poxel SA. Research Support; Self; Danone Nutricia Early Life Nutrition, GlaxoSmithKline plc., Nutricia Advanced Medical Nutrition, Sanofi. J. Szendroedi: None.