Association of the rs3758391 polymorphism in the SIRT1 gene with diabetic nephropathy and decreased estimated glomerular filtration rate (GFR) in a population from southwest Iran

Ramin Tavakoli Faradonbeh,Mehrnoosh Zakerkish,Ali Karimi Akhormeh,Narges Mohammadtaghvaei,Mohammad Taha Jalali,Hamid Yaghooti

Association of the rs3758391 polymorphism in the SIRT1 gene with diabetic nephropathy and decreased estimated glomerular filtration rate (GFR) in a population from southwest Iran

2019

Ramin Tavakoli Faradonbeh
Mehrnoosh Zakerkish
Ali Karimi Akhormeh
Narges Mohammadtaghvaei
Mohammad Taha Jalali
Hamid Yaghooti

Introduction Type 2 diabetes mellitus (T2DM) is a polygenic metabolic disorder. SIRT1 has an essential role in the insulin-signaling pathway and energy homeostasis. SIRT1 exerts protective effects in the kidney cells.

Keywords:

Renal function
Internal medicine
Endocrinology
Population
Diabetes mellitus
Medicine
Metabolic disorder
Diabetic nephropathy
Kidney
Type 2 Diabetes Mellitus
Type 2 diabetes
Allele frequency
Creatinine
Nephropathy
Genotype

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