Discovery of Novel Neuronal Voltage-Dependent Calcium Channel Blockers Based on Emopamil Left Hand as a Bioactive Template

Yuichi Suzuki,Noboru Yamamoto,Yoichi Iimura,Koki Kawano,Teiji Kimura,Satoshi Nagato,Koichi Ito,Makoto Komatsu,Yoshihiko Norimine,Manami Kimura,Tetsuyuki Teramoto,Yoshihisa Kaneda,Takeshi Hamano,Tetsuhiro Niidome,Masahiro Yonaga

Discovery of Novel Neuronal Voltage-Dependent Calcium Channel Blockers Based on Emopamil Left Hand as a Bioactive Template

2003

Yuichi Suzuki
Noboru Yamamoto
Yoichi Iimura
Koki Kawano
Teiji Kimura
Satoshi Nagato
Koichi Ito
Makoto Komatsu
Yoshihiko Norimine
Manami Kimura
Tetsuyuki Teramoto
Yoshihisa Kaneda
Takeshi Hamano
Tetsuhiro Niidome
Masahiro Yonaga

A series of novel neuronal voltage-dependent calcium channel (VDCC) blockers, with inhibitory activity at low micromolar and moderate solubility in water, was discovered by constructing and screening a focused library based on emopamil (1) left hand (ELH) as a bioactive template.

Keywords:

Ether
Solubility
Nitrile
Voltage-dependent calcium channel
Calcium channel
Organic chemistry
Biochemistry
Emopamil
Chemistry
Inhibitory postsynaptic potential

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